Abstract: The importance of evolutionary forces for comparative economic performance across societies has been the focus of a vibrant literature, highlighting the roles played by the Neolithic Revolution as well as the prehistoric \"out of Africa\" migration of anatomically modern humans in generating worldwide variations in the composition of human traits. This essay provides an overview of the literature on the macrogenoeconomics of comparative development, underscoring the significance of evolutionary processes and human population diversity in generating differential paths of economic development across societies. Furthermore, it examines the contribution of Nicholas Wade’s recent hypothesis, regarding the evolutionary origins of comparative development, to this important line of research.